报告时间：2012.10.19. 下午3点

地点：医学综合楼205会议室

主持人：许正平教授

报告人：Marcos Milla

题目：An Overview of Early Drug Discovery in Immunology at Janssen

报告人简介：Marcos Milla obtained his Bachelor’s degree in Biology from Universidad Peruana Cayetano Heredia, Lima, Peru. He then traveled to the USA, where he first obtained his PhD degree in Cell & Molecular Biology from Saint Louis University under the direction of Carlos Hirschberg, working on the mechanism of protein glycosylation in the secretory pathway. After graduating, he became a Jane Coffin Childs Postdoctoral Fellow at the Massachusetts Institute of Technology, working under the supervision of Robert Sauer on protein folding, performing the first alanine scan on a protein, bacteriophage P22 Arc, to understand the relationship between its amino acid sequence and its folding, structural stability and DNA binding function. Then he did a short second postdoctoral training at Duke University, working with Christian Raetz on the biosynthetic pathway of bacterial lipid A. As an independent scientist, he worked first for 3 years at GlaxoSmithKline, participating in the discovery of the TNF-alpha converting enzyme (TACE) and cloning of its cDNA. After that, he joined the Faculty of the Department of Biochemistry and Biophysics of University of Pennsylvania, keeping a focus on TNF biology, proteases and protein-protein interactions. In 2005 he joined Roche Pharmaceuticals, where he led efforts in support of multiple projects in the areas of immunology and neurosciences. Since joining Janssen Pharmaceutical Research & Development in 2009, he led projects within the Immunology Therapeutic Area in early validation, lead discovery or optimization stage. Additionally, he is interested in exploratory research focusing on protein-protein interactions, and the application of “omic” approaches to disease understanding and drug discovery.

 

报告人：Jiao Song

题目：Simplifying Immune Response Quantitation with Mass Spectrometry  

  - High-Throughput Lipidomic Analysis of Eicosanoids

Aug, 2005- Oct 2010: Medicinal Chemistry and Molecular Pharmacology in Purdue University.

Thesis title: Development of mass spectrometric tools for the cellular characterization of protein prenylation

Nov 2010- Jul 2012: Postdoctoral Fellow in Immunology, Drug Discovery, Janssen R&D, Pharmaceutical Companies of Johnson and Johnson

Projects: development of high-throughput mass spectrometry-based method for the quantitative characterization of chemokines and cytokines; development of highthroughput platform for lipidomic analysis of eicosaoinds.

Jul 2012 – present: Scientist, CREATe (Community of research excellence and advanced technology) - Core technology- Analytical Sciences, Janssen R&D

Analytical R&D support for various therapeutic areas (immunology, neuroscience, CVM (cardiovascular metabolisms)