科学研究

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Yong-Mei Cha（查咏梅）教授毕业于上海第二军医大学，1995年在UCSD进行博士后研究，1998年St. Louis University Hospital 住院医师，2000-2004在世界著名医院Mayo Clinic（连续19年全美医院排名第二）的心内科及临床电生理进行Fellow训练。目前在Mayo Clinic任Associate Professor及Consultant，为著名的海外华人医师。主要从事心脏电生理临床及研究工作，在房颤的消融治疗及ICD、CRT等器械治疗方面颇有建树，作为PI或Co-Investigator参与包括CABANA研究在内的大型临床研究十余项。迄今发表学术论文40余篇，其中包括在Am J Physiol，Am J Physiol Heart Circ Physiol，Circulation Res，Circulation，JACC，Heart Rhythm，Nat Clin Pract Cardiovasc Med等心脏领域著名杂志上以第一、通讯作者发表论文20余篇。近年来多次在国际、国内诸多心血管学术会议（如ACC、HRS、长城会、东方会、电生理双年会等）进行学术报告。与国内许多重要医学中心有合作，并指导国内年轻医师进行临床电生理研究。

 

发表主要论文：

1.    Cha YM, Peters BB, Birgersdotter-Green U, Chen P-S: A reappraisal of ventricular fibrillation threshold testing. Am J Physiol. 1993;264:H1005-1010.

2.    Cha YM, Birgersdotter-Green U, Wolf PL, Peters BB, Chen P-S: The mechanism of termination of reentrant activity in ventricular fibrillation. Circulation Res. 1994;74:495-506.

3.    Cha YM, Peters BB, Chen P-S: Use-dependent effects of lidocaine on the upper limit of vulnerability in open-chest dogs. J Am Coll Cardiol. 1994;23:1688-1692.

4.    Cha YM, Uchida T, Wolf PL, Peters BB, Fishbein MC, Karagueuian HS, Chen P-S: The effects of chemical subendocardial ablation on the activation rate gradient during ventricular fibrillation. Am J Physiol. 1995;269:H1998-2009.

5.    Cha YM, Dzeja PP, Shen WK, Jahangir A, Hart CYT, Terzic A, Redfield MM: Failing atrial myocardium: energetic deficits accompany structural remodeling and electrical instability. Am J Physiol Heart Circ Physiol. 2003;284:H1313-H1320.

6.    Cha YM, Redfield MM, Shen WK, Gersh BJ: Atrial fibrillation and ventricular dysfunction: A vicious electro-mechanical cycle. Circulation. 2004;109(23):2839- 43.

7.    Cha YM, Redfield MM, Shah S, Shen WK, Fishbein MC, Chen PS: Effects of omapatrilat on cardiac nerve sprouting and structural remodeling in experimental congestive heart failure. Heart Rhythm. 2005 Sep;2(9):984-90.

8.    Cha YM, Dzeja PP, Redfield MM, Shen WK, Terzic A: Bioenergetic protection of failing atrial and ventricular myocardium by vasopeptidase inhibitor omapatrilat. Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1686-92.

9.    Cha YM, Gersh BJ, Maron BJ, Boriani G, Spirito P, Hodge DO, Weivoda PL, Trusty JM, Friedman PA, Hammill SC, Rea RF, Shen WK: Electrophysiologic manifestations of ventricular tachyarrhythmias provoking appropriate defibrillator interventions in high risk patients with hypertrophic cardiomyopathy. J Cardiovasc Electrophysiol. 2007;18(5):483-7.

10. Cha YM, , Rea RF, Wang M, Shen WK, Asirvatham SJ, Friedman PA, Munger TM, Espinosa RE, Hodge DO, Hayes DL,Redfield MM: Response to cardiac resynchronization therapy predicts survival in heart failure: a single-center experience. J Cardiovasc Electrophysiol. 2007 Sep;18(10):1015-9.

11. Cha YM, Friedman PA, Asirvatham SJ, Shen WK, Munger TM, Rea RF, Brady PA, Jahangir A, Monahan KH, Hodge DO, Meverden RA, Gersh BJ, Hammill SC, Packer DL: Catheter ablation of atrial fibrillation in patients with obesity. Circulation. 2008;117:2583-90. PMID: 18474813

12. Cha, YM, Oh, J, Miyazaki C, Hayes DL, Rea RF, Shen WK, Asirvatham SJ, Kemp BJ, Hodge DO, Chen PS, Chareonthaitawee P: Cardiac resynchronization therapy reverses sympathetic remodeling and upregulates cardiac autonomic control. J Cardiovasc Electrophysiol. 2008 Oct;19(10):1045-52. PMCID: PMC2756798.

13. Miyazaki C, Powell BD, Bruce CJ, Espinosa RE, Redfield MM, Miller FA, Hayes DL, Cha YM, Oh JK: Comparison of echocardiographic dyssynchrony assessment by tissue velocity and strain imaging in subjects with or without systolic dysfunction and with or without left bundle branch block. Circulation. 2008;117:2617-25. PMID: 18474810

14. Liu X-K, Gersh BJ, Cha, YM. Catheter Ablation to cure Tachycardia-induced Cardiomyopathy. Nat Clin Pract Cardiovasc Med. 2008 Jul;5(7):406-10. PMID: 18521108

15. Bunch TJ, Munger TM, Cha YM, Packer DL et al. Substrate and Procedural Predictors of Outcomes after Catheter Ablation for Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy. J Cardiovasc Electrophysiol. 2008 May 8. PMID: 18479329

16. Cha YM, Powell BD, Hammill SC. Prevention of Thromboembolic Stroke in Patients Undergoing Catheter-based Ablation for Atrial Fibrillation: Has it been optimized? J Cardiovasc Electrophysiol 2009 Jul 07. PMID: 19602025

17. Ahmed H, Neuzil P, Cha YM, et al.The esophageal effects of cryoenergy during cryoablation for atrial fibrillation. Heart Rhythm, 2009;6:962-969 PMID: 19560085

18. Wokhlu A, Rea RF, Asirvatham SJ, Webster T, Brooke K, Hodge DO, Wiste HJ, Dong Y, Hayes DL, Cha YM: Upgrade and de novo cardiac resynchronization therapy: impact of paced or intrinsic QRS morphology on outcomes and survival. Heart Rhythm. 2009 Oct;6(10):1439-47. PMID: 19717348

19. Dong K, Shen WK, Powell BD, Dong YX, Rea RF, Friedman PA, Hodge DO, Wiste HJ, Webster T, Hayes DL, Cha YM: Atrioventricular nodal ablation predicts survival benefit in patients with atrial fibrillation and receiving cardiac resynchronization therapy. Heart Rhythm, 2010 Sep;7(9):1240-5. PMID: 20156595

20. Wokhlu A, Cha YM, Packer DL. et al. Long-Term Outcome of Atrial Fibrillation Ablation: Impact and Predictors of Very Late Recurrence. J Cardiovasc Electrophysiol. 2010 May 24.  PMID: 20500237