讲座题目： Roles of BCH domain in cell dynamics control
时间：2010年10月14日（周四）上午9：30
地点：紫金港校区银河线路检测中心综合楼205室
报告人简介：
Curriculum Vitae
Personal Details
Name: Yi Ting ZHOU
Department of Biological Sciences, National University of Singapore,
Block S2, 14 Science Drive4, Singapore 117543.
Email: dbszhouy@nus.edu.sg
Telephone: (65) – 97696592 (mobile), (65) - 6873-7694 (home)
Academic Qualifications and Trainings
Senior Research Fellow (equivalent to Research Assistant Professor)
National University of Singapore, Singapore (2011- )
Research Fellow (class A)
National University of Singapore, Singapore (2008-2010)
Singapore Millennium Foundation Postdoctoral fellow
National University of Singapore, Singapore (2006-2008)
Research Fellow (class B)
National University of Singapore, Singapore (2005-2006)
Ph. D (Cell signaling)
National University of Singapore, Singapore (2000-2005)
Master (Plant Biochemistry and Molecular Biology)
Xiamen University, China (1996-1999)
B. Sc. (Microbiology)
Xiamen University, China (1992-1996)
Awards
2006 Singapore Millennium Foundation Postdoctoral fellowship (Singapore Millennium Foundation)
2005 NUS Research Fellowship (National University of Singapore)
2003 Best Poster Award (4th Sino-Singapore Conference on Biotechnology, National University of Singapore)
2002 Singapore Millennium Scholarship (Singapore Millennium Foundation)
2002 President’s Graduate Fellowship (National University of Singapore)
2001 Best oral presenter award (First Singapore Angiogenesis/Anti-angiogenesis Symposium, National University of Singapore)
2001 Best oral presenter award (6th graduate congress, Department of Biological Sciences, National University of Singapore)
2000 Post-graduate scholarship (National University of Singapore Research Scholarship)
International Journal Publications
1. Zhou, Y.T., Soh, J.K., Shang, X., Guy, G.R and Low, B.C. (2002) The BNIP-2 and Cdc42GAP Homology/sec14p-like Domain of BNIP-S Is a Novel Apoptosis-inducing Sequence.Journal of Biological Chemistry, 277: 7483-7492.
2. Shang, X., Zhou, Y.T., Guy, G.R. and Low, B.C (2003) Concerted Regulation of Cell Dynamics by BNIP-2 and Cdc42GAP Homology/Sec14p-like, Proline-rich, and GTPase-activating Protein Domains of a Novel Rho GTPase-activating Protein, BPGAP1. Journal of Biological Chemistry, 278: 45903-45914.
3. Zhou, Y.T., Guy, G.R and Low, B.C. (2005) BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42 Binding motif within its BNIP-2 and Cdc42GAP Homology domain. Experimental Cell Research, 303:263-274
4. Zhou, Y.T., Guy, G.R and Low, B.C. (2006) BNIP-Sa induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain. Oncogene, 25: 2393-2408
5. Buschdorf, J. P., Chew, L. L., Zhang, B., Cao, Q., Liang, F. Y., Liou, Y. C., Zhou, Y.T., and Low, B.C. (2006) Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. Journal of Cell Science, 119: 3337-3350.
6. Kang, J. S., Bae, G. U., Yi, M. J., Yang, Y. J., Oh, J. E., Takaesu, G., Zhou, Y. T., Low, B. C. and Krauss, R.S. (2008) A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation. Journal of Cell Biology, 182:497-507
7. Zhong, D., Zhang, J., Yang, S., Soh, U. J., Buschdorf, J. P., Zhou Y. T., Yang, D. and Low, B. C. (2009) The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration. Journal of Cell Science,122:414-424
8. Zhou, Y.T. Chew L. L., and Low, B.C.(2010) The BNIP-2 and Cdc42GAP Homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-Activating Protein domain. molecular Biology of the Cell, 21:mbc.E09-05-0408 (Co-correspondent author)
9. Zhou, Y.T. and Low, B.C.(2010) A Comparative Functional Analysis defines the BNIP-2 and Cdc42GAP Homology (BCH) domain as a unique subgroup of Sec14 super family. (Manuscript in preparation, Co-correspondent author)
Selected Conferences Publications
- Zhou, Y.T. Shang, X., Guy, G. R., and Low, B. C. (2001) The BNIP-2 and Cdc42GAP Homology/sec14p-like Domain of BNIP-S Is a Novel Apoptosis-inducing Sequence. The 6th graduate congress. Oral presenter
- Zhou, Y.T. Shang, X., and Low, B. C. (2001) BNIP-S, a Novel Regulator of Apoptosis and GTPases Cell Signaling: its Implication in Cancer and Angiogenesis. First Singapore Angiogenesis/Anti-Angiogenesis Syposium. Oral presenter
- Zhou, Y.T., Shang, X., Guy, G. R., and Low, B. C., (2002) BNIP-2a and b, two regulators of cytoskeleton and GTPases cell signaling. 1st NNI-NUS Neuroscience Symposium. Poster
- Zhou, Y.T., Shang, X., Guy, G. R., and Low, B. C. (2003) Identification of essential residues in the insert region of the mBNIP-2b BCH domain that mediates cell rounding. The 4th Sino-Singapore Conference on Biotechnology. Poster
- Zhou, Y.T. and B. C. Low, (2007) BNIP-2 and Cdc42GAP Homology (BCH) domain as a versatile regulator in cell dynamics and cell signaling. London Research Institute Special Conference: signal Transduction. Poster
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